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目的 探讨大肠癌肝转移因素及对策。方法 对我院 1990年 1月～ 1997年 12月收治的 117例大肠癌肝转移病例 ,进行血清AFP、CEA、HBsAg、肝脏B型超声及CT检查 ,分别施行大肠癌根治、大肠癌根治加肝转移灶切除或微波固化、大肠癌姑息切除 ,大部分病例加行门静脉和区域动脉插管化疗。结果 发现肝转移多见于原发病灶位于乙状结肠 (5 5 .6 % )、有周围淋巴结转移 (76 .1% )、肿瘤超过肠腔一半 (70 .1% ) ,且直径大于 3cm(72 .6 % )、没有明显的肝硬化 (86 % )者。大肠癌根治加肝转移灶切除加门静脉和区域动脉插管化疗 ,3年、5年生存率分别达到 41.7%、2 7.8% ,对多发性肝转移灶行微波固化也能获得较满意效果。结论 进展期乙状结肠癌 ,无肝硬化病例更易发生肝转移。大肠癌根治加肝转移灶切除加门静脉和区域动脉插管化疗是较理想的治疗方法
Objective To explore the factors and countermeasures of liver metastasis of colorectal cancer. Methods A total of 117 patients with liver metastases from January 1990 to December 1997 in our hospital were treated with serum AFP, CEA, HBsAg, liver B-mode ultrasound, and CT scans. They underwent colorectal cancer radical resection, colorectal cancer radical resection and liver resection, respectively. Resection of metastases or microwave solidification, palliative resection of colorectal cancer, in most cases plus portal vein and regional arterial catheterization chemotherapy. The results showed that liver metastases were more common in the primary lesion located in the sigmoid colon (55.6%), with peripheral lymph node metastasis (76.1%), tumors more than half of the intestine (70.1%), and a diameter greater than 3cm (72.6%). %), no significant liver cirrhosis (86%). Colorectal cancer plus liver metastases resection and portal vein and regional arterial cannulation chemotherapy, three-year, 5-year survival rates were 41.7%, 27.8%, respectively, for multiple liver metastases microwave curing can also be more satisfactory results. Conclusion In advanced sigmoid colon cancer, liver metastases are more likely to occur in patients without cirrhosis. Colorectal cancer plus liver metastases resection combined with portal vein and regional arterial intubation chemotherapy is an ideal treatment