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目的研究β-内酰胺类联合大环内酯或喹诺酮治疗老年重症社区获得性肺炎的临床意义。方法 310例老年重症社区获得性肺炎患者,按照随机数字表分为研究组和对照组,每组155例。研究组使用β-内酰胺类联合大环内酯治疗,对照组使用β-内酰胺类联合喹诺酮治疗。比较两组患者临床症状消失时间、临床疗效及患者满意度。结果研究组患者临床症状改善时间以及住院时间均比对照组短(P<0.05)。研究组总有效率为98.06%,明显优于对照组的86.45%(P<0.05)。研究组患者满意度为96.77%,对照组为81.29%,研究组患者满意度显著优于对照组,差异具有统计学意义(P<0.05)。结论老年重症社区获得性肺炎使用联合治疗法有效,且β-内酰胺类联合大环内酯优于联合喹诺酮。
Objective To study the clinical significance of β-lactams combined with macrolide or quinolone in the treatment of elderly patients with severe community-acquired pneumonia. Methods A total of 310 elderly patients with severe community-acquired pneumonia were divided into study group and control group according to random number table, with 155 cases in each group. The study group was treated with β-lactam combined with macrolide and the control group with β-lactam combined with quinolone. The disappearance of clinical symptoms, clinical efficacy and patient satisfaction were compared between the two groups. Results The improvement of clinical symptoms and hospital stay in study group were shorter than those in control group (P <0.05). The total effective rate of the study group was 98.06%, which was significantly better than that of the control group (86.45%, P <0.05). The satisfaction degree of the study group was 96.77%, while the control group was 81.29%. The satisfaction of the study group was significantly better than that of the control group, the difference was statistically significant (P <0.05). Conclusions Combination therapy of elderly patients with severe community-acquired pneumonia is effective, and β-lactam combined with macrolide is superior to combined quinolone.