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目的:探讨磁共振成像(MRI)辅助诊断帕金森病(PD)的价值。方法:对30例PD患者、28例健康对照者进行MRI检查,通过T2加权成像(T2WI)测量黑质致密带(SNc)的宽度,计算分析其与中脑直径的比值和病情的关系;通过灰质抑制成像(GMSI)、白质抑制成像(WMSI)对SNc信号进行观察,在其减影像上进行相对信号值的测量。结果:在T2WI上,PD组SNc的测量宽度(1.173±0.908)mm较对照组(1.722±0.540)mm明显变窄(P=0.027),PD组SNc宽度与中脑直径比值(0.029±0.023)较对照组(0.044±0.014)下降(P=0.017),SNc宽度与病情程度间无显著差异(F=1.484,P=0.236),两者间无明显相关性(r=0.149,P=0.542);在GMSI、WMSI上,PD患者SNc信号丢失以外侧部明显,在其减影图像上,SNc外侧部信号与内侧部信号比值有显著差异(P=0.003 4)。结论:MRI(T2WI、GMSI、WMSI)对辅助诊断PD有应用价值。
Objective: To investigate the value of magnetic resonance imaging (MRI) in the diagnosis of Parkinson’s disease (PD). Methods: Thirty PD patients and 28 healthy controls were examined by MRI. The width of substantia nigra pars compacta (SNc) was measured by T2-weighted imaging (T2WI), and the relationship between the SNc and the ratio of midbrain diameter was calculated. Gray matter inhibition imaging (GMSI), white matter inhibition imaging (WMSI) SNc signal was observed in the subtraction image of the relative signal value measurements. Results: On T2WI, SNc width (1.173 ± 0.908) mm in PD group was significantly narrower than that in control group (1.722 ± 0.540) mm (P = 0.027), and the ratio of SNc width to midbrain diameter in PD group was 0.029 ± 0.023 There was no significant difference between SNc width and severity of disease (F = 1.484, P = 0.236), but no significant correlation was found between them (r = 0.149, P = 0.542) In GMSI and WMSI, the signal loss of SNc in PD patients was obvious in the lateral part, and there was a significant difference (P = 0.003 4) between the SNc lateral part signal and the medial part signal in the subtracted images. Conclusion: MRI (T2WI, GMSI, WMSI) has value in the diagnosis of PD.