论文部分内容阅读
目的了解新疆维吾尔自治区汉族和维吾尔族高尿酸血症患者的相关影响因素。方法从新疆医科大学附属中医医院住院病人中筛选高尿酸血症患者399例,选择同期住院的无高尿酸血症及痛风、无血缘关系的其他疾病患者429例为对照组,分别检测一般身体指标及生化指标,采用ELISA酶联免疫法检测血清白介素-6(IL-6)、肿瘤坏死因子(TNF-α)、C反应蛋白(CRP)。结果与对照组比较,高尿酸组体质指数,脂代谢指标均增高,白介素-6,CRP增高差异有统计学意义;维族患者IL-6、TNF-α两类炎性细胞因子低于汉族高尿酸患者;Logistic回归分析结果表明,性别、体质指数,脂代谢指标,IL6、CRP均与高尿酸相关。结论高尿酸血症与肥胖、血脂异常等代谢综合征存在共同的发病基础;慢性炎症状态与高尿酸血症相关,可明显影响高尿酸血症的发生发展;不同民族异常代谢和炎性细胞因子有不同特点。
Objective To understand the related factors of hyperuricemia in Han and Uygur nationality in Xinjiang Uygur Autonomous Region. Methods A total of 399 patients with hyperuricemia were selected from inpatients of the Affiliated TCM Hospital of Xinjiang Medical University. 429 patients without hyperuricemia and gout who were hospitalized in the same period were selected as the control group, and the general physical indexes Serum IL-6, TNF-α and C-reactive protein (CRP) were detected by enzyme linked immunosorbent assay. Results Compared with the control group, the indexes of body mass index and lipid metabolism were increased in hyperuricemia group and the levels of interleukin-6 and CRP were increased significantly. The inflammatory cytokines IL-6 and TNF-α in Uygur were lower than those in Han Patients; Logistic regression analysis showed that gender, body mass index, lipid metabolism indicators, IL6, CRP are associated with hyperuricemia. Conclusion Hyperuricemia and obesity, dyslipidemia and other metabolic syndrome exist common pathogenesis; chronic inflammatory state associated with hyperuricemia, can significantly affect the occurrence and development of hyperuricemia; abnormal metabolism of different ethnic groups and inflammatory cytokines Have different characteristics.