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目的探讨卡培他滨联合奥沙利铂治疗进展期胃癌的近期疗效及对生活质量的影响。方法选取经病理检查确诊的进展期胃癌患者87例,随机分为观察组44例和对照组43例。观察组给予卡培他滨联合奥沙利铂治疗,对照组给予表阿霉素+顺铂+氟尿嘧啶(ECF)方案治疗。比较2组近期疗效,详细记录治疗期间毒副反应的发生情况,并观察治疗前后生活质量的改善情况。结果观察组有效率为61.36%,显著高于对照组的39.53%(P<0.05)。观察组骨髓抑制、胃肠道反应发生率均显著低于对照组(P<0.05),丙氨酸氨基转移酶(GPT)升高、血尿素氮(BUN)升高、色素沉着及脱发等发生率均无显著差异(P>0.05)。治疗后,2组躯体、情绪、认知、角色、社会等各维度评分及总分显著增加(P<0.01),其中观察组增加幅度显著大于对照组(P<0.01)。结论卡培他滨联合奥沙利铂治疗进展期胃癌疗效好,且明显改善患者的生活质量。
Objective To investigate the short-term effect of capecitabine combined with oxaliplatin on advanced gastric cancer and its impact on quality of life. Methods Totally 87 patients with advanced gastric cancer diagnosed by pathology were randomly divided into observation group (44 cases) and control group (43 cases). The observation group received capecitabine combined with oxaliplatin and the control group received epirubicin + cisplatin + fluorouracil (ECF) regimen. Compare the short-term curative effect of two groups, record the occurrence of side effects during treatment and observe the improvement of quality of life before and after treatment. Results The effective rate of the observation group was 61.36%, which was significantly higher than that of the control group (39.53%, P <0.05). The incidence of bone marrow suppression and gastrointestinal reaction in observation group were significantly lower than those in control group (P <0.05), elevated alanine aminotransferase (GPT), increased blood urea nitrogen (BUN), pigmentation and hair loss No significant difference (P> 0.05). After treatment, the scores of body, emotion, cognition, role, society and other dimensions in two groups increased significantly (P <0.01), and the increase in observation group was significantly greater than that in control group (P <0.01). Conclusion Capecitabine combined with oxaliplatin in the treatment of advanced gastric cancer has a good effect and significantly improves the quality of life of patients.