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目的研究重庆地区人群结直肠癌发病危险与体力活动之间的关系。方法进行院内病例-对照研究,478名有效病例和838名对照均选自于2002年1月至2004年6月在第三军医大学3所附属医院住院治疗的重庆本地居民患者,并按年龄相差5岁以内、性别和居住地相同的条件进行配对。采用条件逻辑回归方法计算OR值,表示与疾病危险性的关联程度。结果重体力/极重体力劳动使直肠癌的危险显著增加(OR=1.49,95%C:I 1.03~2.17),对结肠癌没有显著影响。而每日保持适当的直立活动时间(2~5 h/d)避免久坐(卧)则对直肠癌有显著保护效应(OR=0.6,95%CI:0.36~0.99)。10年前的体重指数、锻炼频率、睡眠时间等因素对直肠癌或结肠癌均无显著影响。结论体力活动程度对结直肠癌尤其是直肠癌的发病可能存在不同影响。
Objective To study the relationship between the risk of colorectal cancer and physical activity in Chongqing population. Methods In-hospital case-control study, 478 valid cases and 838 controls were all from Chongqing residents who were hospitalized in 3 affiliated hospitals of the Third Military Medical University from January 2002 to June 2004. The patients were divided by age Within 5 years of age, sex and place of residence to match the same conditions. The conditional logistic regression method was used to calculate the OR value, indicating the degree of association with disease risk. The results of heavy physical / heavy manual labor so that the risk of rectal cancer increased significantly (OR = 1.49, 95% C: I 1.03 ~ 2.17), no significant effect on colon cancer. And to maintain appropriate appropriate time of upright activities (2 ~ 5 h / d) to avoid sedentary (lying) have a significant protective effect on rectal cancer (OR = 0.6,95% CI: 0.36 to 0.99). 10 years ago, body mass index, exercise frequency, sleep time and other factors have no significant effect on rectal cancer or colon cancer. Conclusion The degree of physical activity may have different effects on the incidence of colorectal cancer, especially rectal cancer.