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目的:探讨PTEN、VEGF蛋白表达在原发性上皮性卵巢癌发生、发展、转移中的作用及临床病理学意义。方法:利用SP法对正常卵巢(32例)、卵巢良性肿瘤(31例)、上皮性卵巢癌(74例)PTEN、VEGF基因蛋白的表达进行检测。结果:①PTEN在上皮性卵巢癌表达缺失率及VEGF表达率分别高于对照组,P<0.01;②PTEN在浆液性囊腺癌表达缺失率高于黏液性囊腺癌,P<0.05,晚期表达缺失率高于早期,P<0.01,G3表达缺失率高于G1+G2,P<0.05;③VEGF晚期的阳性率高于早期,P<0.05,淋巴结转移阳性组高于阴性组,P<0.05;④PTEN蛋白表达与VEGF表达不相关。结论:PTEN表达缺失、VEGF蛋白表达在上皮性卵巢癌的发生、发展、侵袭中有重要作用;PTEN、VEGF同时发生异常可作为评估卵巢癌恶性程度的重要生物学指标。
Objective: To investigate the role of PTEN and VEGF protein in the genesis, development and metastasis of primary epithelial ovarian cancer and its clinicopathological significance. Methods: The expressions of PTEN and VEGF in normal ovary (32 cases), benign ovarian tumor (31 cases) and epithelial ovarian cancer (74 cases) were detected by SP method. Results: (1) The expression of PTEN in epithelial ovarian cancer was significantly higher than that in control group (P <0.01). ②The loss of PTEN expression in serous cystadenocarcinoma was higher than that in mucinous cystadenocarcinoma (P <0.05) The rate of G3 expression was higher than that of G1 + G2, P <0.05; ③The positive rate of late stage of VEGF was higher than that of early stage, P <0.05, the positive rate of lymph node metastasis was higher than that of negative group, P <0.05; ④PTEN Protein expression is not related to VEGF expression. CONCLUSION: The loss of PTEN expression and the expression of VEGF protein play an important role in the occurrence, development and invasion of epithelial ovarian cancer. Concurrent abnormalities of PTEN and VEGF can be used as important biological indexes to evaluate the malignant degree of ovarian cancer.