目的 :探讨ｐ1 6基因纯合子缺失和点突变与儿童急性白血病 (ＡＬ)发生、发展及预后的关系。方法 :用聚合酶链反应 (ＰＣＲ)、ＤＮＡ单链构象多态性 (ＳＳＣＰ)分析和ＤＮＡ测序技术研究 53例初治和复发儿童ＡＬ及 30例对照组ｐ1 6基因纯合子缺失和点突变的情况。结果 :儿童ＡＬ Objective: To investigate the relationship between the deletion and mutation of p1 6 gene and the occurrence, development and prognosis of childhood acute leukemia (AL). Methods: The homozygous deletion and point mutation of p1 6 gene in 53 children with newly diagnosed and relapsed children and 30 controls were studied by polymerase chain reaction (PCR), single strand conformation polymorphism (SSCP) and DNA sequencing Happening. Results: Children AL