Nicorandil,即N-2-羟乙基烟酰胺硝酸盐是一较新的血管舒张药,已被成功地用于治疗心绞痛,其舒张小动脉管平滑肌的作用是通过膜电压依赖性钙通道,减少Ca~(2+)内流面传递的。这种活性作用对治疗充血性心力衰竭(CHF)也很有效。Galie等人报道了该药用于治疗少数已服用洋地黄(digitalis)和利尿药治疗的病人的情况,在使用该药至少15d前必须停用这类药物。治疗CHF的目的是通过降低心脏压力,达到心脏舒张平衡,提高机体耐受性,同时改 Nicorandil, N-2-hydroxyethylnicotinamide nitrate, is a newer vasodilator that has been successfully used to treat angina pectoris and its effect of relaxing the arteriole smooth muscle is mediated through a membrane voltage-dependent calcium channel that reduces Ca ~ (2 +) inflow surface. This activity is also effective in the treatment of congestive heart failure (CHF). Galie et al reported that the drug was used to treat a small number of patients who had been treated with digitalis and diuretics and had to discontinue the drug for at least 15 days prior to using the drug. The purpose of the treatment of CHF is to reduce cardiac pressure, achieve diastolic balance, improve body tolerance, while changing