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目的：探讨奥氮平联合多奈哌齐治疗脑器质性精神障碍的临床疗效和安全性。方法将82例脑器质性精神障碍患者随机分为两组，均接受脑器质性疾病常规治疗及口服奥氮平治疗，研究组在此基础上联合多奈哌齐治疗。于治疗前后采用简明精神病量表、阳性与阴性症状量表、日常生活能力量表评定临床疗效及不良反应。结果治疗后两组各量表评分均较治疗前显著降低（P＜0．01），研究组显著低于对照组（P＜0．01）；两组不良反应发生率比较差异无显著性（P＞0．05）。结论奥氮平联合多奈哌齐治疗脑器质性精神障碍临床疗效显著，安全性高，优于单用奥氮平治疗。“,”Objective To explore the efficacy of olanzapine plus donepezil in the treatment of brain organic psychosis (BOP) .Methods Eighty-two BOP patients were randomly divided into 2 groups ,both groups received conventional therapy for brain organic disease and took orally olanzapine ,on this basis research group was plus donepezil .Efficacies and adverse reac-tions were assessed with the Brief Psychiatric Rating Scale (BPRS) ,Positive and Negative Syndrome Scale (PANSS) and Activities of Daily Living (ADL) before and after treatment .Results After treatment all scales scores lowered more significantly compared with pretreatment (P<0 .01) ,those were significantly lower in research than control group (P0 .05) .Conclusion Olanzapine plus donepezil has an evident effect and higher safety compared with single olanzapine in the treatment of brain organic psychosis .