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目的:分析寻常型银屑病患者阿维A治疗相关药物不良反应（ADR）及停药原因。方法:收集广西医科大学第一附属医院2014—2019年使用阿维A治疗的寻常型银屑病患者292例，回顾性分析其中符合纳入与排除标准且能够定期随访的193例患者的临床资料，统计用药期间出现的ADR及停药原因。结果:193例中171例出现519例次ADR，发生率为88.6%。ADR累及上皮组织174例次（33.5%）、内分泌系统126例次（24.3%）、生殖系统1例次（0.2%）、运动系统29例次（5.6%）、循环系统77例次（14.8%）、神经系统3例次（0.6%）、消化系统71例次（13.7%）、泌尿系统38例次（7.3%）。相对常见的ADR为皮肤黏膜干燥、肌肉骨骼疼痛，常见的生化指标改变为血脂异常、血小板升高、肝酶异常。ADR的报告时间主要分布在开始用药后1个月内（81.6%）。罕见ADR有脱发、耳鸣、甲沟炎、肌无力、感觉异常、头痛、月经紊乱和高胆红素血症，报告时间主要分布在患者开始用药后1~6个月内（70.6%）。519例次ADR中，324例次无需药物干预能好转、痊愈，195例次经停药和/或药物干预后好转、痊愈，无病重或死亡病例。193例患者中，已停药186例，其中116例（62.4%）因病情好转停药，35例（18.8%）因ADR导致用药依从性差而停药，27例（14.5%）因ADR在医师指导下停药；8例（4.3%）因病情控制不佳停药。结论:阿维A治疗寻常型银屑病相关ADR发生率高，但大都预后良好。“,”Objective:To analyze adverse drug reactions (ADR) and reasons for drug discontinuation during acitretin therapy in patients with psoriasis vulgaris.Methods:A total of 292 patients with psoriasis vulgaris treated with acitretin were collected from the First Affiliated Hospital of Guangxi Medical University from 2014 to 2019. According to the inclusion and exclusion criteria, 193 patients who received periodic follow-up were included in this study, clinical data were collected from these patients and retrospectively analyzed. ADRs occurring during the acitretin treatment and reasons for drug discontinuation were analyzed.Results:Totally, 519 cases of ADRs occurred in 171 of the 193 patients, with the incidence rate being 88.6%. Of these cases, 174 (33.5%) involved the epithelial tissues, 126 (24.3%) the endocrine system, 1 (0.2%) the reproductive system, 29 (5.6%) the motor system, 77 (14.8%) the circulatory system, 3 (0.6%) the nervous system, 71 (13.7%) the digestive system, and 38 (7.3%) involved the urinary system. Relatively common ADRs included dryness of skin and mucous membranes, as well as musculoskeletal pain, and common biochemical changes included dyslipidemia, elevated platelets, and abnormal aminotransferase levels. Most ADRs (81.6%) were reported within 1 month after the start of acitretin therapy. Rare ADRs included alopecia, tinnitus, paronychia, myasthenia, sensory abnormalities, headache, menstrual disorders and hyperbilirubinemia, which were mainly (70.6%) reported within 1 to 6 months after the start of therapy. Of the 519 cases of ADRs, 324 could be alleviated or subsided without drug intervention, 195 were alleviated or subsided after drug withdrawal and/or drug intervention, and there were no cases of serious illness or death. Among the 193 patients, 186 had discontinued acitretin therapy, of whom 116 (62.4%) discontinued due to improvement in disease condition, 35 (18.8%) discontinued due to ADR-induced poor medication compliance, 27 (14.5%) discontinued under the guidance of clinicians due to ADRs, and 8 (4.3%) discontinued due to poor disease control.Conclusion:The incidence of adverse reactions to acitretin is high in the treatment of psoriasis vulgaris, but most of them have a good prognosis.