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目的观察养血清脑颗粒联合帕罗西汀对脑梗死后抑郁及神经功能康复的影响与安全性。方法将116例脑梗死后抑郁症患者随机分为治疗组58例,对照组58例,在脑梗死临床路径治疗基础上,治疗组给予养血清脑颗粒4g,3次/d,口服,盐酸帕罗西汀片每日20mg,早晨口服,6周为1个疗程;对照组给予盐酸帕罗西汀片6周为1个疗程。于治疗前、治疗后第2周、第4周、第6周采用24项汉密尔顿量表(HAMD)、日常生活能力量表(BI)和美国国立卫生研究院脑卒中量表(NIHSS)进行评分。结果治疗组汉密尔顿抑郁量表(HAMD)评分及美国国立卫生研究院脑卒中量表(NIHSS)评分较对照组显著下降(P<0.05),治疗组日常生活能力量表(BI)评分较对照组明显提高(P<0.05)。结论养血清脑颗粒联合帕罗西汀对脑梗死后抑郁及神经功能缺损的改善疗效显著,安全性高,依从性好。
Objective To observe the effect and safety of Yangxue Qingnao Granules combined with paroxetine on depression and neurological rehabilitation after cerebral infarction. Methods One hundred and sixteen patients with depression after cerebral infarction were randomly divided into treatment group (58 cases) and control group (58 cases). On the basis of the clinical pathological treatment of cerebral infarction, the treatment group was given Yangxue Qingnao granule 4g, 3 times / d orally, Rostirmine tablets daily 20mg, morning oral, 6 weeks for a course of treatment; control group was given paroxetine hydrochloride tablets for 6 weeks for a course of treatment. HAMD, BI, and NIHSS were used to score scores before treatment, 2 weeks, 4 weeks and 6 weeks after treatment. . Results The Hamilton Depression Rating Scale (HAMD) score and NIHSS score of the treatment group were significantly lower than those of the control group (P <0.05). The BI scores of the treatment group were significantly lower than those of the control group Significantly increased (P <0.05). Conclusion Yangxue Qingnao Granules combined with paroxetine have significant effects on the improvement of depression and neurological deficits after cerebral infarction. They are safe and have good compliance.