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目的探讨血清可溶性细胞间粘附分子－１（ｓＩＣＡＭ－１）在实验性变态反应性神经炎（ＥＡＮ）中的作用。方法用兔坐骨神经匀浆加完全福氏佐剂（ＣＦＡ）免疫大鼠，建立ＥＡＮ模型；同时用抗细胞间粘附分子－１（ＩＣＡＭ－１）单克隆抗体注入大鼠体内后再诱导ＥＡＮ；观察自然病程组、抗体注射组及对照组的发病情况与病理特点；应用双抗体夹心ＥＬＩＳＡ法检测不同发病程度ＥＡＮ动物血清中ｓＩＣＡＭ－１的浓度。结果抗体注射组发病率及发病程度明显低于自然病程组；自然病程组ｓＩＣＡＭ－１的浓度高于抗体注射组及对照组；ＥＡＮ发病程度与ｓＩＣＡＭ－１的浓度呈正比。结论ｓＩＣＡＭ－１与ＥＡＮ的发病关系密切，ｓＩＣＡＭ－１的测定是观测自身免疫性疾病的一个有用的指标；抗ＩＣＡＭ－１抗体能够减轻或预防ＥＡＮ的发生。
Objective To investigate the role of serum soluble intercellular adhesion molecule-1 (sICAM-1) in experimental allergic neuritis (EAN). Methods Rabbit sciatic nerve homogenate plus complete Freund’s adjuvant (CFA) was used to immunize rats to establish EAN model. At the same time, ICAM-1 monoclonal antibody was injected into rats to induce EAN. The pathogenesis and pathological features of natural disease course group, antibody injection group and control group were observed. The serum concentration of sICAM-1 in EAN animals with different disease severity was detected by double antibody sandwich ELISA. Results The incidence and the incidence of antibody in the antibody injection group were significantly lower than those in the natural course group. The concentration of sICAM-1 in the natural course group was higher than that in the antibody injection group and the control group. The incidence of EAN was proportional to the concentration of sICAM-1. Conclusions sICAM-1 is closely related to the pathogenesis of EAN. The determination of sICAM-1 is a useful indicator for the detection of autoimmune diseases. Anti-ICAM-1 antibody can reduce or prevent the occurrence of EAN.