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为降低卡那霉素临床用量,达到降低其毒副反应,但尚保持或提高疗效的目的。通过平皿试验,以枯草杆菌为检定菌株,优选TMP增效卡那霉素抗菌作用的最适宜比例;不同比例卡那霉素与定量TMP组合的最佳抗菌作用。结果表明卡那霉素与TMP之比为20u:1μg制剂最为理想。其对大肠杆菌、变形杆菌、绿脓杆菌可增效2~4倍;但对金黄色葡萄球菌、八叠球菌不显示增效作用。复方中的TMP不影响卡那霉素与血清蛋白的结合率;对小鼠保护试验结果表明复方卡那霉素的作用强于卡那霉素;但对家鸽平均致死量及对小鼠的LD_(50),两药比较其t值均无显著差异。
To reduce the clinical use of kanamycin, to reduce its toxicity, but still maintain or improve the efficacy of the purpose. Bacillus subtilis as the tested strain by plate test, the best proportion of antibacterial effect of TMP synergistic kanamycin is the best antibacterial activity of different proportion of kanamycin and quantitative TMP. The results showed that kanamycin and TMP ratio of 20u: 1μg of the most ideal preparation. Its Escherichia coli, Proteus, Pseudomonas aeruginosa 2 to 4 times the synergistic effect; but Staphylococcus aureus, Sarcina sachet does not show synergistic effect. Compound TMP does not affect the kanamycin and serum protein binding rate; protection test results showed that the compound kanamycin than kanamycin, but the average lethal dose of pigeons and mice LD_ (50), two drugs compared t value were no significant difference.