放射治疗是肿瘤治疗的主要手段之一,而肿瘤细胞的放射敏感性是决定放疗疗效的关键因素之一,大量的研究表明细胞周期调控是影响细胞辐射敏感性的重要因素之一,p16基因与细胞周期调控有关,人类75%的癌细胞株有p16基因的缺失或突变,其低表达与肿瘤细胞增殖、辐射抵抗密切相关。随 Radiation therapy is one of the main means of tumor therapy, and the radiosensitivity of tumor cells is one of the key factors that determine the efficacy of radiotherapy. A large number of studies have shown that cell cycle regulation is one of the important factors that affect the radiation sensitivity of cells. Cell cycle regulation, 75% of human cancer cell lines have p16 gene deletion or mutation, the low expression of tumor cell proliferation, radiation resistance are closely related. With