细胞核转录因子核因子-κB是一种作用广泛的转录因子,在高等生物受外界免疫、应力和炎症等刺激后发生的细胞早期反应以及相关基因表达方面起着重要的调节作用,参与炎症反应、生长调控和细胞凋亡。研究表明,核因子-κB信号通路的过度活化与人类疾病的发生关系密切,在眼科有关疾病中亦发挥作用。 Nuclear factor-κB (NF-κB) is a widely used transcription factor that plays an important regulatory role in early cellular response and related gene expression after being stimulated by external immunity, stress and inflammation in higher organisms. It is involved in the inflammatory response, Growth Regulation and Apoptosis. Studies have shown that the over-activation of the nuclear factor-kappa B signaling pathway is closely related to the occurrence of human diseases and plays a role in ophthalmological diseases.