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目的探讨部分血液指标与肌萎缩侧索硬化(ALS)患者预后的关系,寻找预测ALS患者预后的血液学标志物。方法回顾性分析2007年1月至2012年12月山东大学齐鲁医院收治的116例ALS患者的临床资料和血常规检查结果,采用Kaplan-Meier生存分析计算中位生存时间,Log-rank分析各单因素变量与生存时间的关系,Cox风险比例模型分析多变量对生存时间的影响。结果生存曲线分析显示,具有较高水平白蛋白、肌酐(s Cr)、甘油三酯(TG)、低密度脂蛋白/高密度脂蛋白(LDL/HDL)、尿酸(UA)的患者生存时间较长,其中s Cr、TG水平与ALS患者生存期呈显著的剂量依赖效应(P<0.05)。多因素分析显示,s Cr是影响ALS患者预后的独立因素。结论血脂水平和营养状态与ALS患者预后密切相关,s Cr可作为预测ALS患者预后的血液学标志物。
Objective To investigate the relationship between some blood indexes and the prognosis of patients with amyotrophic lateral sclerosis (ALS) and find the hematological markers to predict the prognosis of patients with ALS. Methods The clinical data and blood test results of 116 patients with ALS admitted to Shandong Qilu Hospital from January 2007 to December 2012 were retrospectively analyzed. The median survival time was calculated by Kaplan-Meier survival analysis. Log-rank analysis was performed on each single The relationship between factor variables and survival time, Cox risk proportional model analysis of multivariate impact on the survival time. Results Survival curve analysis showed that the survival time of patients with higher levels of albumin, creatinine (Cr), triglyceride (TG), LDL / HDL, and uric acid (UA) There was a significant dose-dependent effect of s Cr and TG levels on the survival of patients with ALS (P <0.05). Multivariate analysis showed that s Cr was an independent factor affecting the prognosis of patients with ALS. Conclusion Serum lipids and nutritional status are closely related to the prognosis of patients with ALS. S Cr can be used as a hematologic marker to predict the prognosis of patients with ALS.