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临床观察表明,心肌梗塞(MI)后可发生左室肥大,据认为其可能是恢复期心功能改善的机理之一。但对MI 后心肌肥大的建立与发展的动态过程研究甚少,它与心泵功能改善的关系也未阐明。Rubin 等(1981)报道,于闭塞冠脉后5周观察到左室梗塞范围>15%的大鼠有左室局部心肌肥大(Regi-onal myocardial fiber hypertrophy),但据pfeffer(1980)报告,大鼠冠脉闭塞后3
Clinical observations show that left ventricular hypertrophy can occur after myocardial infarction (MI), which is thought to be one of the mechanisms of cardiac function improvement during convalescence. However, there are few studies on the dynamic process of the establishment and development of cardiac hypertrophy after MI, and the relationship between cardiac function and cardiac pump function has not been elucidated yet. Rubin et al. (1981) reported a Regi-onal myocardial fiber hypertrophy in rats with LV infarction> 15% 5 weeks after occlusion of the coronary arteries, but according to pfeffer (1980) After coronary occlusion 3