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目的探讨动脉自旋标记(arterial spin labeling,ASL)与动态磁敏感对比增强(dynamic susceptibility-weighted contrast enhanced,DSC)技术在颅内肿瘤鉴别中的临床应用价值。方法经病理证实的35例颅内肿瘤患者,其中胶质瘤20例,转移瘤15例。对所有患者行3.0TMR常规扫描、ASL序列(Q2TIPS)、DSC灌注扫描以及增强扫描,得到两种检查方法的CBF图。所得数据Kruskal-Wallis检验分析,P<0.05为差异有统计学意义;两种灌注方法的相关性用直线回归分析的方法。结果①ASL法与DSC法在3组中TBF/对侧脑白质CBF、TBF/对侧半球CBF、TBF/对侧脑灰质CBF比值差异均有统计学意义(P<0.05)。②两种方法测得的上述比值均密切相关(r分别为0.91、0.92、0.91,P<0.01)。结论 ASL及DSC均可用于颅内肿瘤微血管灌注的评估,两者具有高度相关性。
Objective To investigate the clinical value of arterial spin labeling (ASL) and dynamic susceptibility-weighted contrast enhanced (DSC) in differentiating intracranial tumors. Methods 35 cases of intracranial tumors confirmed by pathology, including 20 cases of glioma and 15 cases of metastases. All patients underwent 3.0 TMR routine scan, ASL sequence (Q2TIPS), DSC perfusion scan and enhanced scan, CBF map of the two methods were obtained. The data Kruskal-Wallis test analysis, P <0.05 for the difference was statistically significant; correlation between the two perfusion method using linear regression analysis. Results ① There were significant differences in CBF ratio between TBF / contralateral white matter CBF, TBF / contralateral hemisphere CBF and contralateral gray matter CBF in both groups (P <0.05). ② The above two ratios were closely correlated (r = 0.91,0.92,0.91, P <0.01, respectively). Conclusion Both ASL and DSC can be used to evaluate the microvascular perfusion of intracranial tumors, both of which are highly correlated.