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作者用CEA(癌胚抗原)、IMA(肠粘液抗原)及M_1(胃粘液抗原)之备相应特异抗体血清在组织免疫学方面检查正常人组织,结果没有查出CEA,仅在肠的杯状细胞中特异地查出了IMA,在胃的腺窝组织中查出了M_1.对胎儿组织检查.发现胎儿不仅胃肠上皮CEA阳性,而且都同时发现了IMA与M_1.此外还发现,成人(胃癌及大肠癌患者)胃肠上皮癌及非癌组织,凡CEA阳性之部位的粘液,都与胎儿一样,IMA及M_1均呈阳性。这表明粘液抗原IMA及M_1与CEA一样也可以成为有价值的肿瘤标志物. 方法以25个13～30周龄胎儿消化道组织片及52
The authors used CEA (Carcinoembryonic Antigen), IMA (Intestinal Mucus Antigen), and M_1 (Gastric Mucus Antigen) for preparation of appropriate antibody serum to examine normal human tissue in terms of histoimmunology. As a result, CEA was not detected, but only in the intestine. IMA was specifically detected in cells, and M_1 was detected in the glandular follicles of the stomach. Examination of fetal tissue revealed that the fetus was not only positive for CEA in the gastrointestinal epithelium, but also found IMA and M_1 at the same time. Also found that adults ( Gastric cancer and colorectal cancer patients) Gastrointestinal epithelial cancer and non-cancer tissues, where the CEA positive site of mucus, are the same as the fetus, IMA and M_1 were positive. This shows that the mucus antigens IMA and M_1 can be used as valuable tumor markers as well as CEA. Methods 25 25- to 30-week-old fetal digestive tissue slices and 52