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目的观察针刺配合奥拉西坦胶囊治疗轻中度血管性痴呆的临床疗效。方法将76例轻中度血管性痴呆患者进行了临床随机对照前瞻性研究,其中38例为治疗组,采用针刺配合奥拉西坦胶囊治疗;38例为对照组,采用针刺配合尼莫地平片治疗。于治疗用药前、后第12周和第24周采用简易精神状态检查(MMSE)和Blessed-Roth痴呆量表(BDS)评定患者的认知功能、社会活动功能及日常生活能力。结果治疗24周后,治疗组MMSE得分23.73±2.53高于对照组MMSE得分19.73±3.66;治疗组BDS得分7.12±5.07低于对照组BDS得分9.43±4.64。治疗组总有效率为86.84%,对照组总有效率为76.32%。结论针刺配合奥拉西坦胶囊的中西医结合治疗方法,对轻中度VD患者智力状态和生活能力有明显的改善。
Objective To observe the clinical effect of acupuncture combined with Oxiracetam in the treatment of mild to moderate vascular dementia. Methods A total of 76 patients with mild to moderate vascular dementia were prospectively randomized prospectively. Among them, 38 were treated with acupuncture combined with Oxiracetam, 38 were as control group, Flat sheet treatment. The cognitive function, social function and daily living ability of patients were assessed by MMSE and BDS before and 12 weeks and 24 weeks after treatment. Results After 24 weeks of treatment, the MMSE score of the treatment group was 23.73 ± 2.53, which was higher than that of the control group (19.73 ± 3.66). The BDS score of the treatment group was 7.12 ± 5.07, which was lower than that of the control group (9.43 ± 4.64). The total effective rate was 86.84% in the treatment group and 76.32% in the control group. Conclusion Acupuncture combined with Oxiracetam in the treatment of Integrative Medicine, mild to moderate VD patients with mental status and viability significantly improved.