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目的探讨移植前内膜厚度对冻融胚胎移植(FET)妊娠结局的预测价值。方法回顾性分析1261个FET周期的临床资料,利用ROC曲线分析移植前内膜厚度与妊娠结局的关系,计算内膜厚度的界值并进行分组,对各组的一般情况、临床资料及妊娠结局进行分析。结果根据ROC曲线计算其约登指数,得到内膜厚度的界值为9mm,根据这一内膜厚度将患者分为A组(≤9mm)和B组(>9mm),比较两组的一般情况,移植胚胎数、不孕因素、用药方案及临床妊娠率,年龄及临床妊娠率的差异有统计学意义(P<0.05)。进一步排除年龄因素的影响,在以内膜厚度分组的基础上按照年龄35岁分组比较妊娠率,在≤35岁组随着内膜厚度的增加妊娠率明显升高(P<0.05)。结论 FET周期中,移植前内膜厚度对妊娠结局有一定的预测价值,尤其对于≤35岁患者,尽可能的增加内膜厚度是提高临床妊娠率的有效方式。
Objective To investigate the predictive value of preimplantation intima thickness on pregnancy outcome of frozen-thawed embryo transfer (FET). Methods The clinical data of 1261 FET cycles were retrospectively analyzed. The ROC curve was used to analyze the relationship between the thickness of the intima before transplantation and the outcome of pregnancy. The cut-off values of intima thickness were calculated and grouped. The general situation, clinical data and pregnancy outcome Analyze. Results The Youden index was calculated according to ROC curve, and the cut-off value of intima thickness was 9mm. Patients were divided into group A (≤9mm) and group B (> 9mm) according to the thickness of the intima. , The number of embryos transferred, infertility factors, drug regimen and clinical pregnancy rate, age and clinical pregnancy rate were significantly different (P <0.05). Further exclusion of the impact of age factors, based on the group of intima-media thickness according to 35-year-old group compared pregnancy rates, ≤35 years old group with intimal thickness pregnancy increased significantly (P <0.05). Conclusion FET cycle, the thickness of the intima before transplantation for pregnancy outcome has some predictive value, especially for patients ≤ 35 years, as much as possible to increase the thickness of the intima is to improve the clinical pregnancy rate is an effective way.