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目的观察倍他乐克在治疗老年充血性心力衰竭中的临床疗效。方法选择老年充血性心力衰竭患者96例,随机分为对照组和治疗组。对照组48例,应用常规强心、利尿、扩血管药物治疗。治疗组48例,在应用抗心力衰竭常规药物治疗的基础上加用倍他乐克,初始剂量6.25mg,每日2次,缓慢加量到25mg,每日2次,疗程10周。观察治疗前后患者心功能改善情况等临床指标的变化,评估倍他乐克的临床疗效和安全性。结果治疗组显效36例,有效8例,无效4例,总有效率为91.67%(44/48)。对照组显效24例,有效l0例,无效14例,总有效率为70.83%(34/48)。治疗后两组之间的总有效率、心率和心功能改善情况差异均有统计学意义(P<0.05)2组治疗前后心率血压变化治疗组明显优于对照组。结论在常规抗心衰治疗基础上加用倍他乐克治疗充血性心力衰竭效果显著,可明显改善心功能和临床症状,提高患者生活质量。
Objective To observe the clinical efficacy of metoprolol in the treatment of senile congestive heart failure. Methods 96 elderly patients with congestive heart failure were randomly divided into control group and treatment group. The control group of 48 cases, the application of conventional cardiac, diuretic, vasodilator drug treatment. In the treatment group, 48 patients received Betaloc on the basis of routine antihypertensive drug treatment. The initial dose was 6.25 mg twice daily and the dosage was slowly increased to 25 mg twice daily for 10 weeks. Observed before and after treatment in patients with improved cardiac function and other clinical indicators of change, evaluation of metoprolol clinical efficacy and safety. Results The treatment group markedly effective in 36 cases, effective in 8 cases, 4 cases, the total effective rate was 91.67% (44/48). In the control group, 24 cases were markedly effective, 10 cases were effective and 14 cases were ineffective. The total effective rate was 70.83% (34/48). After treatment, the total effective rate, heart rate and cardiac function improvement between the two groups were statistically significant (P <0.05) before and after treatment, heart rate and blood pressure changes in the treatment group was significantly better than the control group. Conclusion The treatment of congestive heart failure with Betaloc on the basis of routine anti-heart failure treatment has significant effect, which can obviously improve the cardiac function and clinical symptoms and improve the quality of life of patients.