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目的探讨H型高血压患者血清同型半胱氨酸(Hcy)水平与早期肾损害的关系。方法选择符合条件的高血压患者178例,根据Hcy水平将患者分为H型高血压组(Hcy≥10μmol/L)91例和单纯性高血压组(Hcy<10μmol/L)87例,并选取同期查体健康人90例作为健康组,比较3组性别、年龄、体质量指数、常规生化指标及血清Hcy、胱抑素C水平和尿β2-微球蛋白水平的差异,Pearson相关分析Hcy水平与各指标之间的关系,同时以Hcy为因变量进行多元线性回归分析。结果 H型高血压组患者年龄及血清胱抑素C、尿β2-微球蛋白水平均明显高于健康组及单纯高血压组(P均<0.05)。Pearson相关分析发现,H型高血压患者Hcy水平和血清胱抑素C(r=0.709,P<0.05)、尿β2-微球蛋白(r=0.646,P<0.05)、年龄(r=0.695,P<0.05)呈正相关,多元逐步回归分析显示Hcy水平与血清胱抑素C(β=4.725,P<0.05)、尿β2-微球蛋白(β=4.637,P<0.05)、年龄(β=0.213,P<0.05)存在线性关系。结论 H型高血压患者血清Hcy水平与早期肾损害具有相关性。
Objective To investigate the relationship between serum homocysteine (Hcy) level and early renal damage in patients with Hypertension. Methods A total of 178 eligible hypertensive patients were selected and divided into Hypertension group (Hcy≥10μmol / L) and Hypertension group (Hcy <10μmol / L) Ninety healthy people were selected as healthy group in the same period. The differences of sex, age, body mass index, routine biochemical indexes, serum Hcy, cystatin C and urinary β2-microglobulin in the three groups were compared. Pearson correlation analysis And the relationship between the indicators, while Hcy as the dependent variable multiple linear regression analysis. Results The age, serum cystatin C and urinary β2-microglobulin in Hypertension group were significantly higher than those in healthy group and simple hypertensive group (all P <0.05). Pearson correlation analysis found that the Hcy levels in patients with Hypertension and serum cystatin C (r = 0.709, P <0.05), urinary β2-microglobulin (r = 0.646, P <0.05). The multiple stepwise regression analysis showed that the correlation between Hcy and serum cystatin C (β = 4.725, P <0.05), urinary β2- microglobulin (β = 4.637, 0.213, P <0.05). Conclusion The level of serum Hcy in patients with Hypertension is correlated with early renal damage.