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目的探讨帕罗西汀对以心血管症状为主的惊恐发作的疗效及安全性。方法 84例以心血管症状为主的惊恐发作患者,随机分成观察组和对照组,各42例。观察组使用帕罗西汀治疗,对照组使用舍曲林治疗,记录并比较两组周胸痛发作次数、汉密尔顿焦虑量表(HAMA)评分、治疗效果、用药期间不良反应发生情况。结果两组治疗2、4、8、12周的周胸痛发作次数均少于治疗前,差异均具有统计学意义(P<0.05);两组治疗2、4、8、12周的HAMA评分均低于治疗前,差异均具有统计学意义(P<0.05)。观察组治疗2、4、8、12周的周胸痛发作次数及HAMA评分均优于对照组,差异具有统计学意义(P<0.05)。观察组治疗总有效率92.9%高于对照组的69.0%,差异具有统计学意义(P<0.05)。两组用药期间均未发生严重不良反应,观察组不良反应发生率16.7%与对照组的26.2%比较差异无统计学意义(χ2=1.13,P>0.05)。结论帕罗西汀对以心血管症状为主的惊恐发作的治疗效果明显,无明显副作用。
Objective To investigate the efficacy and safety of paroxetine in the treatment of panic attacks based on cardiovascular symptoms. Methods Eighty-four patients with panic symptoms were randomly divided into observation group (n = 42) and control group (n = 42). The patients in the observation group were treated with paroxetine. The control group was treated with sertraline. The number of weekly chest pain episodes, the Hamilton Anxiety Scale (HAMA) score, the therapeutic effect and adverse reactions during the treatment were recorded and compared. Results The number of weekly chest pain episodes at 2, 4, 8, and 12 weeks were less than those before treatment in both groups (P <0.05). HAMA scores at 2, 4, 8 and 12 weeks in both groups were significantly lower than those before treatment Before treatment, the differences were statistically significant (P <0.05). The frequency of chest pain episodes and HAMA scores in observation group at 2, 4, 8 and 12 weeks were better than those in control group, with statistical significance (P <0.05). The total effective rate of observation group was 92.9% higher than 69.0% of control group, the difference was statistically significant (P <0.05). No serious adverse reactions occurred during the two groups. The incidence of adverse reactions in the observation group was 16.7% compared with 26.2% in the control group (χ2 = 1.13, P> 0.05). Conclusion Paroxetine is effective in treatment of panic attacks based on cardiovascular symptoms without obvious side effects.