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血管紧张素 (Ang )是肾素 -血管紧张素系统 (RAS)中最为重要的活性激素 ,它在高血压的病理生理中起着重要的作用。Ang 的作用通过细胞表面的 Ang 受体介导 ,根据与不同受体拮抗剂的选择性可将其受体分为两个亚型 :AT1 受体和 AT2受体。已知的 Ang 的生理作用是由 AT1 受体介导的 ,AT2 受体的功能尚不清楚。在临床上主要有两种抑制 RAS活性的药物 :一是血管紧张素转化酶抑制剂 (ACEI) ,它抑制 Ang 的生成 ;二是 AT1 受体拮抗剂 ,它阻断 Ang 相应受体的生理学作用。AT1 受体拮抗剂的潜在临床实用性正在得到深入研究
Angiotensin (Ang) is the most important active hormone in renin-angiotensin system (RAS) and plays an important role in the pathophysiology of hypertension. The role of Ang through the cell surface Ang receptor mediated, according to the selectivity of different receptor antagonists can be divided into two subtypes its receptor: AT1 receptor and AT2 receptor. It is known that the physiological role of Ang is mediated by the AT1 receptor, and the function of the AT2 receptor is unclear. There are two clinically important drugs that inhibit RAS activity: one is an angiotensin-converting enzyme inhibitor (ACEI) that inhibits the production of Ang and the other is an AT1 receptor antagonist that blocks the physiological role of the Ang receptor . The potential clinical utility of AT1 receptor antagonists is being studied in depth