资料表明,氧自由基参与了失血性休克时细胞损伤过程,并且氧自由基损伤可能是失血性休克不可逆发展的机制之一。本实验用川芎嗪注射液治疗家兔失血性休克,旨在从再灌注损伤角度观察其防治作用并探讨其机制。材料与方法一、动物分组健康大耳白兔18只,雌雄兼有,体重1.5～2.0kg,由湖北医学院动物室提供。随机分为3组,每组6只:A组为平衡盐组,B组为(超氧化物歧化酶SOD)平衡盐组,C组为川芎嗪平衡盐组。二、失血性休克模型巴比妥钠45mg/kg腹腔注射麻醉。待动物完全麻醉后,无菌操作下,切开分离左侧颈动脉及右侧颈内静脉,分别插入G_(22)、G_(23)动、静 The data shows that oxygen free radicals participate in the process of cell damage during hemorrhagic shock, and oxygen free radical damage may be one of the mechanisms of irreversible development of hemorrhagic shock. In this experiment, tetramethylpyrazine injection was used to treat hemorrhagic shock in rabbits, aiming to observe its prevention and treatment from the perspective of reperfusion injury and explore its mechanism. Materials and Methods 1. Animals There were 18 healthy big white rabbits, both male and female, weighing 1.5 to 2.0 kg, provided by the animal room of Hubei Medical College. They were randomly divided into 3 groups with 6 rats in each group: group A was a balanced salt group, group B was a superoxide dismutase (SOD) balanced salt group, and group C was a tetramethylpyrazine balanced salt group. Second, hemorrhagic shock model Barbital sodium 45mg/kg intraperitoneal injection of anesthesia. After the animal is fully anesthetized, aseptically, the left carotid artery and the right internal jugular vein are dissected and separated, and G_(22), G_(23) are inserted and moved respectively.