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念珠菌是临床上深部真菌感染的主要致病菌,随着抗真菌药物的广泛应用,临床念珠菌耐药性变得严重。本文综述了念珠菌对各类常用抗真菌药物如唑类、多烯类、棘白菌素类等的耐药机制研究进展,为进一步开展念珠菌耐药机制研究及指导临床合理使用抗真菌药物提供理论依据。
Candida albicans is the main pathogen of clinical deep fungal infection. With the wide application of antifungal drugs, clinical candidiasis becomes more serious. This article reviews the progress of Candida albicans on the resistance mechanisms of various commonly used antifungal drugs such as azoles, polyenes, and echinocandins. In order to further investigate the mechanism of drug resistance in Candida and to guide clinical rational use of antifungal agents Provide a theoretical basis.