目的比较中西医结合与单纯应用西药治疗抑郁症的安全性。方法将188例抑郁症患者随机分为2组,分别应用中西医结合与西药治疗,疗程4周,用副反应量表(TESS)评定不良反应。结果4周末2组不良反应具有显著性差异。结论中药可明显减少抗抑郁药引起的不良反应。 Objective To compare the safety of integrated traditional Chinese and Western medicine with western medicine in the treatment of depression. Methods One hundred and eighty-eight patients with depression were randomly divided into two groups, which were treated with integrated traditional Chinese and Western medicine and western medicine respectively. The course of treatment was 4 weeks. Adverse reactions were assessed with TESS. Results There were significant differences in adverse reactions between the two groups at the end of the 4th week. Conclusion Chinese medicine can significantly reduce the adverse reactions caused by antidepressants.