论文部分内容阅读
目的探讨早期(术后3个月)高危型HPV检测在宫颈上皮内瘤变患者宫颈环形电切术(LEEP)术后随访中的临床价值。方法术后3个月采用第2代杂交捕获试验技术检测接受LEEP术的134例宫颈上皮内瘤变(CIN)患者的HPV-DNA含量,对比检测结果与CIN残留或复发的关系。结果术后3个月CIN患者术后HPV-DNA的阳性率均显著低于治疗前,差异有统计学意义(P<0.05);术后3个月HPV-DNA阳性的患者其残留率及复发率均显著高于阴性者,差异均有统计学意义(P<0.01)。结论术后3个月的HPV-DNA检测在判断CIN患者LEEP手术效果、病毒清除效果及预测病变是否残留或复发方面均有较高的价值。
Objective To investigate the clinical value of high-risk HPV testing in early stage (3 months after surgery) in the follow-up of cervical ring excision (LEEP) in patients with cervical intraepithelial neoplasia. Methods The level of HPV-DNA in 134 patients with cervical intraepithelial neoplasia (CIN) undergoing LEEP surgery was detected by the second generation hybridization capture assay at 3 months after operation. The relationship between the results and CIN residual or recurrence was examined. Results The positive rate of HPV-DNA in CIN patients at 3 months after operation was significantly lower than that before treatment (P <0.05). The residual rate and recurrence of HPV-DNA positive patients at 3 months after operation Rates were significantly higher than negative, the difference was statistically significant (P <0.01). Conclusions The HPV-DNA test at 3 months after surgery has high value in judging the LEEP operation effect, virus clearance effect and predicting the residual or recurrence of LEEP in CIN patients.