论文部分内容阅读
目的研究痛风消颗粒与其功能主治有关的药效学。方法采用大鼠痛风性关节炎模型及大鼠急性血瘀模型观察治疗痛风性关节炎和活血化瘀的作用,采用小鼠高尿酸血症模型观察降低尿酸的作用,采用小鼠扭体法和耳肿胀法分别观察镇痛、消炎的作用。结果与结论痛风消颗粒对急性炎症有较强的抗炎作用,且能降低尿酸,同时还具有一定外周镇痛和活血化瘀作用,为临床治疗急性痛风性关节炎提供了药理学依据。
Objective To study the pharmacodynamics of Tongfengxiao Granules on its indications of function. Methods The rat models of gouty arthritis and acute blood stasis model were used to observe the effects of treating gouty arthritis and promoting blood circulation and removing blood stasis. The mice model of hyperuricemia was used to observe the effect of reducing uric acid. The mice writhing method and Ear swelling method were observed analgesic, anti-inflammatory effect. RESULTS AND CONCLUSION Tongfengxiao Granule has a strong anti-inflammatory effect on acute inflammation, and can reduce uric acid. It also has certain peripheral analgesic and blood-activating and blood-stasis effects and provides a pharmacological basis for clinical treatment of acute gouty arthritis.