目的 :为探讨超高速 CT检测的冠状动脉钙化与冠状动脉管腔狭窄之间的关系。方法 :从 8例压力灌注固定后的心脏标本中分离出 2 0支冠状动脉 ,拉直后 ,超高速 CT扫描 ;每支冠状动脉分成相应的 3mm血管段 ,组织切片 ,地衣红染色 ,L eica图像分析仪上计算冠状动脉管腔面积狭窄率。结果 :在 4 84个血管段中 ,无粥样病变血管段的钙化率、钙化面积、钙化积分 (0 ,0 ,0 )明显低于有粥样病变的血管段 (2 8% ,1.74 %和 6 .73,P<0 .0 1)和管腔狭窄≥ 75%的血管段 (54.4 % ,5.8和 2 2 .7,P<0 .0 1) ;狭窄程度越大 ,钙化率越高 ;尽管冠状动脉钙化阴性的血管段可能有粥样硬化存在 ,但是只有 8.4 %的血管段属于管腔面积狭窄≥ 75% ;超高速 CT检测管腔面积狭窄≥ 75%的血管段敏感性、特异性分别为 54.4 %、81.5%。结论 :冠状动脉狭窄程度越重 ,粥样硬化内钙化发生率越高 ;冠状动脉钙化阴性有着重要的临床意义 ;CT阈值≥ 130 Hu于国人可能偏高 Objective: To investigate the relationship between coronary artery calcification and coronary artery stenosis by ultra-high-speed CT. METHODS: Twenty coronary arteries were isolated from 8 cardiac specimens fixed by pressure perfusion. After straightening, they were scanned by ultra-high-speed CT. Each coronary artery was divided into corresponding 3 mm vascular segments. Tissue sections, lichen red staining, Image analyzer to calculate the coronary stenosis area of ​​the lumen. Results: The calcification rate, calcification area and calcification score (0, 0, 0) of atherosclerotic vascular segments were significantly lower than those of atherosclerotic vascular segments (28%, 1.74% and 6 .73, P <0.01) and vascular segments ≥ 75% (54.4%, 5.8 and 22.7, P <0.01). The greater the degree of stenosis was, the higher the rate of calcification was. Although coronary artery calcification-negative vascular segments may have atherosclerosis, only 8.4% of the vascular segments belong to the stenosis ≥ 75%; ultra-high-speed CT detection of the lumen area narrowed ≥ 75% of vascular sensitivity, specificity Respectively 54.4%, 81.5%. Conclusion: The more severe coronary stenosis, the higher the incidence of calcification in atherosclerosis; the negative coronary artery calcification has an important clinical significance; CT threshold ≥ 130 Hu may be high in Chinese people