论文部分内容阅读
目的分析2型糖尿病发生下肢动脉病变的相关因素。方法对328例2型糖尿病患者进行病史调查、体格检查、生化检查和下肢动脉彩色多普勒超声检查。根据下肢动脉彩色多普勒超声检查结果,将病例按下肢动脉病变的严重程度的不同分成无病变、轻度病变、中度病变、重度病变四组,找出具有组间差异的因素,分析它们与下肢动脉病变严重程度的相关性,并利用logistic逐步回归分析方法筛选出下肢动脉病变的独立危险因素。结果 328例患者中有下肢血管病变者246例(75.0%),其中轻度92例(28.0%),中度111例(33.8%),重度43例(13.1%)。下肢动脉病变严重程度与年龄、糖尿病病程、高血压病程、冠心病病程、糖尿病肾病病史、收缩压、空腹血糖、餐后2 h血糖、尿微量白蛋白、血肌酐呈正相关(P<0.01),与BMI呈负相关(P<0.01)。下肢动脉病变的独立危险因素是餐后2 h血糖(优势比为1.28,P<0.01)、年龄(优势比为1.11,P<0.01)。结论 2型糖尿病患者下肢动脉病变发生率较高。2型糖尿病发生下肢动脉病变的独立可调控危险因素是餐后2 h血糖,下肢动脉病变严重程度与收缩压、空腹血糖、餐后2 h血糖呈正相关。应该积极控制血糖和血压,避免或延缓下肢动脉病变的发生、发展。
Objective To analyze the related factors of lower extremity arterial disease in type 2 diabetes mellitus. Methods 328 patients with type 2 diabetes mellitus were investigated by history, physical examination, biochemical examination and color Doppler ultrasonography of lower extremity arteries. According to the results of color Doppler ultrasonography of lower extremity arteries, the cases were divided into four groups: non-lesion, mild lesion, moderate lesion and severe lesion according to the severity of lower extremity arterial disease, and to find out the factors with differences between groups And the severity of lower extremity arterial disease. Logistic stepwise regression analysis was used to screen independent risk factors for lower extremity arterial disease. Results Of the 328 patients, 246 (75.0%) had lower extremity vascular lesions, of which 92 were mild (28.0%), 111 (33.8%) were moderate and 43 (13.1%) were severe. The severity of lower extremity arterial disease was positively correlated with age, duration of diabetes, duration of coronary artery disease, history of coronary heart disease, history of diabetic nephropathy, systolic blood pressure, fasting blood glucose, postprandial blood glucose, urinary albumin and serum creatinine (P <0.01) And BMI was negatively correlated (P <0.01). The independent risk factor for lower extremity arterial disease was 2-hour postprandial blood glucose (odds ratio 1.28, P <0.01) and age (odds ratio 1.11, P <0.01). Conclusions Patients with type 2 diabetes have a lower incidence of arterial disease. The independent and controllable risk factor of lower extremity arterial disease in type 2 diabetes mellitus was 2-hour postprandial blood glucose, and the severity of lower extremity arterial disease was positively correlated with systolic blood pressure, fasting blood glucose and 2-hour postprandial blood glucose. Should actively control blood sugar and blood pressure, to avoid or delay the occurrence and development of lower extremity arterial disease.