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目的:探讨硫酸镁对新生儿窒息后合并缺氧缺血性脑病的防治效果。方法:将81例在妇产科出生的窒息新生儿随机分为治疗组和对照组,对照组给常规综合治疗,治疗组在常规治疗的基础上于12、24、48 h加用硫酸镁治疗。结果:治疗组合并HIE 6例(19.3%),对照组合并HIE 14例(46.6%),差异有统计学意义(χ2=4.61,P<0.05)。结论:硫酸镁在窒息后12 h内应用可以有效阻断继发性脑损伤的发展,对减少窒息后HIE的发生、降低致残率,有积极意义。
Objective: To investigate the prevention and treatment effect of magnesium sulfate on neonatal asphyxia with hypoxic-ischemic encephalopathy. Methods: Eighty-one neonates with asphyxia born in obstetrics and gynecology were randomly divided into treatment group and control group. The control group was given conventional comprehensive treatment. The treatment group was treated with magnesium sulfate at 12, 24 and 48 h on the basis of routine treatment . Results: There were 6 cases (19.3%) in the treatment group and 14 cases (46.6%) in the HIE group, the difference was statistically significant (χ2 = 4.61, P <0.05). Conclusion: The application of magnesium sulfate within 12 h after asphyxiation can effectively block the development of secondary brain injury. It is of great significance to reduce the occurrence of HIE and reduce the disability after asphyxia.