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目的验证口服黄体酮胶囊—益玛欣的孕激素活性;探讨其应用于体外受精-胚胎移植(IVF-ET)的临床意义。方法2006-06-2006-09对福建省妇幼保健院8例非子宫性闭经患者行人工周期治疗,口服益玛欣前后取血查孕酮,个别患者口服益玛欣后取子宫内膜活检。另将IVF-ET患者52例,随机分为2组。研究组26例,给予益玛欣+黄体酮;对照组26例,单纯给予黄体酮。所有患者于注HCG日及取卵后8d取血查孕酮。结果(1)8例人工周期治疗患者,益玛欣用药后与用药前比较,血孕酮明显升高(P<0.01),其中1例用药后子宫内膜活检提示中分泌期子宫内膜。(2)IVF-ET两组患者血孕酮水平及妊娠率差异无显著性(P>0.05)。结论口服黄体酮胶囊—益玛欣具有明显的孕激素活性;用于IVF-ET的临床疗效与黄体酮针剂效果相似,是IVF-ET周期补充黄体功能的另一可供选择的药物。
Objective To verify the progesterone activity of oral progesterone capsule-yimaxin and to explore its clinical significance in IVF-ET. Methods From June 2006 to June 2006, 8 cases of non-uterine amenorrhea patients undergoing MCH in Fujian MCH hospital were treated with artificial cyclophosphamide before and after oral administration of Yimaxin. Some patients received endometrial biopsy after oral administration of Yimaxin. Another 52 cases of IVF-ET patients were randomly divided into two groups. Study group, 26 cases were given yimaxin + progesterone; control group, 26 cases, given progesterone alone. All patients on the HCG injection day and after ovulation 8d blood test progesterone. Results (1) In the 8 patients treated with artificial cycle, the blood progesterone was significantly increased (P <0.01) after the treatment of Yimaxin and before treatment, and the endometrial biopsy showed that the endometrial biopsy in 1 case showed endometriosis. (2) There was no significant difference in blood progesterone level and pregnancy rate between the two groups (P> 0.05). Conclusions Oral progesterone capsule-yimaxin has obvious progestin activity. The clinical efficacy of IVF-ET is similar to that of progesterone injection. It is another alternative medicine for IVF-ET cycle supplement of luteal phase.