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目的探讨糖皮质激素治疗基质型单疱病毒性角膜炎的临床疗效。方法选取绵竹市中医医院2013年8月—2015年8月收治的基质型单疱病毒性角膜炎患者90例,根据随机数字表法分为对照组和观察组,各45例。对照组患者给予常规抗病毒治疗,观察组患者在对照组基础上给予注射用甲泼尼龙琥珀酸钠。比较两组患者临床疗效、治疗时间、不良反应发生情况及复发率。结果观察组患者临床疗效优于对照组(P<0.05)。观察组患者治疗时间短于对照组(P<0.05)。观察组患者不良反应发生率、复发率低于对照组(P<0.05)。结论在常规治疗基础上给予糖皮质激素治疗基质型单疱病毒性角膜炎的临床疗效确切,可有效缩短治疗时间,降低复发率,且安全性高。
Objective To investigate the clinical efficacy of glucocorticoid in the treatment of herpes simplex keratitis. Methods Totally 90 patients with matrix-type herpes simplex keratitis admitted from August 2013 to August 2015 in Mianzhu Hospital of Traditional Chinese Medicine were divided into control group and observation group according to random number table method, with 45 cases in each group. Patients in the control group were given conventional antiviral therapy. Patients in the observation group were given methylprednisolone succinate for injection on the basis of the control group. The clinical efficacy, treatment time, incidence of adverse reactions and relapse rate were compared between the two groups. Results The clinical efficacy of the observation group was better than that of the control group (P <0.05). The observation group patients shorter treatment time than the control group (P <0.05). Adverse reactions in observation group patients, the recurrence rate was lower than the control group (P <0.05). Conclusions The clinical curative effect of glucocorticoid on the treatment of herpes simplex virus keratitis on the basis of routine treatment is exact, which can effectively shorten the treatment time, reduce the recurrence rate and have high safety.