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目的 :探讨 CD44 S和 CD44 V6 在胃淋巴瘤中的表达特征及其临床意义。方法 :采用 HE染色、CD3、CD2 0 、CD44 S和 CD44 V6 的免疫组化法观察 47例胃淋巴瘤。结果 :CD44 S在低度恶性胃淋巴瘤中的阳性率为 2 7% ,高度恶性为6 2 % ,差异显著 (P =0 .0 2 ) ;CD44 V6 在低度胃淋巴瘤中的阳性率为 6 % ;高度恶性为 38% ,差异显著 (P =0 .0 1)。CD44 S在临床 I期的阳性率为 30 % ,II～ 期为 75 % ,差异显著 (P =0 .0 0 2 )。结论 :CD44 S和 CD44 V6 的表达与胃淋巴瘤的恶性程度相关 ,而且随着临床分期的进展 ,CD44 S的表达增强
Objective: To investigate the expression of CD44 S and CD44 V6 in gastric lymphoma and its clinical significance. Methods: 47 cases of gastric lymphoma were observed by HE staining, immunohistochemistry of CD3, CD20, CD44 S and CD44 V6. Results: The positive rate of CD44 S in low-grade gastric lymphoma was 27% and the high grade was 62% (P = 0. 02). The positive rate of CD44 V6 in low-grade gastric lymphoma Was 6%; high malignant was 38%, the difference was significant (P = 0.01). The positive rate of CD44 S in clinical stage I was 30%, and the stage II ~ 75%. The difference was significant (P = 0.00002). Conclusion: The expressions of CD44 S and CD44 V6 are correlated with the degree of malignancy of gastric lymphoma. With the progress of clinical stage, the expression of CD44 S is enhanced