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目的探讨孕妇生殖道解脲支原体(UU)和沙眼衣原体(CT)感染与胎膜早破(PROM)发生之间的关系,为阐明PROM病因及早期干预治疗提供依据。方法 PROM患者150例(研究组)和正常孕妇200例(对照组),实时荧光PCR方法检测UU和CT的表达。结果 (1)研究组UU及CT的检出率分别为50.7%和24.0%,,均高于对照组(均P<0.05)。研究组的UU和CT感染总阳性率亦高于对照组(P﹤0.05),(62.7%vs 36.5%)。(2)研究组中发生早产的孕妇UU和CT的感染率分别为83.3%、47.6%,均高于足月产孕妇(均P﹤0.05)。结论 UU和CT感染是引起孕妇PROM的重要原因之一,感染UU和CT容易造成PROM孕妇发生早产的可能,对母婴的影响较大,应重视孕妇生殖道UU和CT感染的筛查和治疗。
Objective To investigate the relationship between genital UU and CT infection and premature rupture of membranes (PROM) in pregnant women and to provide basis for elucidating the etiology and early intervention of PROM. Methods 150 cases of PROM patients (study group) and 200 normal pregnant women (control group), real-time fluorescent PCR method to detect the expression of UU and CT. Results (1) The detection rates of UU and CT in the study group were 50.7% and 24.0%, respectively, higher than those in the control group (all P <0.05). The total positive rates of UU and CT in the study group were also higher than those in the control group (62.7% vs 36.5%, P <0.05). (2) The prevalence of UU and CT in pregnant women with preterm birth in study group were 83.3% and 47.6%, respectively, which were higher than that of full-term pregnant women (all P <0.05). Conclusions UU and CT infection are one of the most important causes of PROM in pregnant women. UU and CT are likely to cause premature birth in PROM pregnant women and have a greater impact on mothers and infants. UU and CT infection should be emphasized in the screening and treatment of pregnant women .