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随着微量元素研究不断深入,其生理作用逐渐被认识,人类许多疾病的发生、发展都与微量元素有关,如:癌症、心血管病、脑病、神经系统疾患、糖尿病、肝病、地方病、营养缺乏症等。微量元素在体内多以结合态存在,并以结合态(主要是络合物)参与复杂的生理和病理过程。生物体是一个复杂的络合平衡系统,生物微量元素的作用机制是微量元素与生物配体协同作用,在体内完成多种生物功能,如作为载体进行物质和电子传递,储备必需性金属离子以及重金属离子的解毒等等。金属络合物药物也存在金属离子和有机配体间的相互作用,
With the deepening of the research on trace elements, its physiological role has gradually been recognized. Many human diseases are related to the occurrence and development of trace elements such as cancer, cardiovascular diseases, encephalopathies, nervous system diseases, diabetes, liver diseases, endemic diseases and nutritional deficiencies Disease and so on. Trace elements in the body mostly exist in the binding state, and the binding state (mainly complex) involved in complex physiological and pathological processes. Organism is a complicated system of complexation and balance. The mechanism of action of trace elements in biology is that synergistic action of trace elements and biological ligands can accomplish a variety of biological functions in vivo, such as substance and electron transfer as carrier, reserve essential metal ions and Detoxification of heavy metal ions and so on. Metal complex drugs also exist the interaction between metal ions and organic ligands,