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非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)指包括单纯性脂肪肝,以及由其演变成的非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH),甚至肝硬化等一系列病变的综合征。肥胖和静态生活方式可诱发基因重组导致NAFLD的发生;肝脏与肠道和脂肪组织间的相互关联、基因和环境间持续的相互作用,故在儿童NAFLD的发病机制中上述因素占有重要作用。目前人们对儿童NAFLD的自然史认识不多,正逐步深入研究其发病机理。发病机制和组织学改变不仅可为早期诊断和非侵入性诊断手段的应用提供依据,还可为儿童NAFLD的诊治提供新思路。
Non-alcoholic fatty liver disease (NAFLD) refers to the simple fatty liver, and its evolution into non-alcoholic steatohepatitis (non-alcoholic steatohepatitis, NASH), and even a series of cirrhosis Syndrome of disease. Obesity and static lifestyles can induce genetic reassociation leading to the occurrence of NAFLD; liver and intestine and adipose tissue interrelated, genetic and environmental continuous interaction, so the pathogenesis of NAFLD in children play an important role in these factors. At present, people have little understanding of the natural history of children with NAFLD, and are gradually studying their pathogenesis. Pathogenesis and histological changes not only provide the basis for early diagnosis and noninvasive diagnosis, but also provide new ideas for the diagnosis and treatment of NAFLD in children.