自20世纪60年代以来,器官移植逐渐成为终末期器官功能衰竭患者的常规治疗选择。随着新型高效免疫抑制药物在临床的广泛应用,器官移植后急性排斥反应已基本能被控制,但对慢性排斥反应却缺乏有效的治疗手段,同时长期使用免疫抑制药物会使受者发生恶性肿瘤、难以控制的感染等一系列不良反应,故对于抑制器官移植术后的排斥反应一直是近数十年 Organ transplantation has gradually become a routine treatment option for patients with end-stage organ failure since the 1960s. With the widespread use of new and highly effective immunosuppressive drugs in clinical practice, acute rejection after organ transplantation has been basically controlled, but there is a lack of effective treatment for chronic rejection, and long-term use of immunosuppressive drugs can cause malignant tumors in recipients , Difficult to control the infection and a series of adverse reactions, it is for the suppression of rejection after organ transplantation has been in recent decades