神经病理性疼痛是神经系统损伤引起的一种慢性疼痛，由于其发病机制尚未完全阐明，目前尚缺乏有效的治疗手段，因此进一步探求维持慢性病理性疼痛状态的机制至关重要。近年来研究发现，L型电压门控钙通道（ VGCC）在神经病理性疼痛中起关键作用。该文将近年来 L型 VGCC 在神经病理性疼痛中的研究进展予以综述，旨在为神经病理性疼痛的临床治疗提供参考。“,”Neuropathic pain is defined as a chronic pain initiated or caused by the lesion of the nervous system.Its pathogenesis is still not totally clear.Most treatments have been empirically established,and their efficacy sometimes remains unsatisfactory .It is therefore necessary to pursue a deeper understanding of the mechanisms maintaining chronic neuropathic pain states .Recently,it is found that L-type voltage-guted calcium channels VGCC play an important role in neuropathic pain .Here is to make a review focusing on the research progress of the L-type VGCC in neuropathic pain so as to provide information for its clinical therapy .