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[目的]探讨奥曲肽联合肠内营养治疗小儿急性胰腺炎的临床疗效和对IL-2、IL-6的影响。[方法]将2011年8月~2013年8月间我院收治的59例急性胰腺炎患儿使用分层随机分组法分为对照组28例和治疗组31例,对照组患儿给予肠内营养,治疗组患儿给予肠内营养联合奥曲肽2.5μg/kg静脉滴注,治疗结束后比较临床疗效及患儿的腹部压痛消失时间、腹痛缓解时间、血液淀粉酶和尿液淀粉酶恢复时间,测定血清中IL-2和IL-6的水平。[结果]治疗组总有效率为90.3%,与对照组(75.0%)比较差异有统计学意义(Z=2.14,P<0.05);治疗组腹痛缓解时间、腹部压痛消失时间和血、尿液淀粉酶恢复时间均明显少于对照组,差异有统计学意义(P<0.05);治疗后两组患儿IL-6明显下降(P<0.05),IL-2水平升高(P<0.05);且治疗组IL-6水平的变化更明显,与对照组相比差异有统计学意义(P<0.05)。[结论]奥曲肽联合肠内营养进行治疗能明显改善急性胰腺炎患儿的临床症状和体征,降低炎性因子水平,是临床上治疗急性胰腺炎较为有效的方法。
[Objective] To investigate the clinical efficacy of octreotide combined with enteral nutrition in the treatment of acute pancreatitis in children and its effect on IL-2 and IL-6. [Method] The 59 cases of acute pancreatitis admitted to our hospital from August 2011 to August 2013 were divided into control group (n = 28) and treatment group (n = 31) by stratified stratified stratified method. The control group Nutrition, treatment group given enteral nutrition combined with intravenous injection of octreotide 2.5μg / kg, after treatment compared the clinical efficacy and the disappearance of abdominal tenderness in children with time, abdominal pain relief time, blood amylase and urine amylase recovery time, Serum levels of IL-2 and IL-6 were measured. [Results] The total effective rate in the treatment group was 90.3%, which was significantly different from that in the control group (Z = 2.14, P <0.05). The pain relief time, disappearance time of abdominal tenderness and blood and urine The recovery time of amylase was significantly less than that of the control group (P <0.05). The levels of IL-6 and IL-2 in the two groups were significantly decreased (P <0.05) (P <0.05). The change of IL-6 in the treatment group was more obvious than that in the control group (P <0.05). [Conclusion] The combination of octreotide and enteral nutrition can significantly improve the clinical symptoms and signs of children with acute pancreatitis and reduce the levels of inflammatory cytokines. It is a more effective method for the treatment of acute pancreatitis in clinic.