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目的探讨瓜蒌薤白半夏汤方加减(自拟心痛3号方)预防冠状动脉支架内再狭窄的临床疗效。方法选择2015年1月—2016年4月该院心内科行支架术的冠心病患者108例,分为观察组51例及对照组57例,围术期分别予瓜蒌薤白半夏汤方加减(自拟心痛3号方)及辛伐他汀口服。观察二组疗效、支架内再狭窄发生率、主要不良反应发生率等。结果观察组49例和对照组42例完成随访,随访时间6~9个月,支架内再狭窄发生率分别为6.1%(3/49)和7.1%(3/42),差异无统计学意义(P>0.05)。二组患者均未出现严重的不良反应。结论瓜蒌薤白半夏汤方加减(自拟心痛3号方)预防冠心病支架置入术后再狭窄的效果与辛伐他汀相似、且价格低廉。
Objective To investigate the curative effect of Guajiluobanbangxia Decoction (self-made Tongtong No.3 prescription) on the prevention of coronary stent restenosis. Methods From January 2015 to April 2016, 108 cases of coronary heart disease undergoing cardiothoracic surgery in our hospital were divided into observation group (n = 51) and control group (n = 57). Perioperative period was given Less (since heartache on the 3rd party) and simvastatin orally. Two groups were observed efficacy, the incidence of in-stent restenosis, the incidence of major adverse reactions. Results 49 cases of observation group and 42 cases of control group were followed up for 6 to 9 months, the incidence of in-stent restenosis was 6.1% (3/49) and 7.1% (3/42), respectively, with no significant difference (P> 0.05). Two groups of patients did not appear serious adverse reactions. Conclusions The effect of preventing and treating restenosis of coronary heart disease patients after coronary stenting is similar to that of simvastatin, and its price is low.