目的探讨颅咽管瘤内放疗的长期治疗结果。方法对743例立体定向32 P内放疗的囊性颅咽管瘤患者进行长期疗效回顾性分析,术后门诊复查及电话随访10～20年(平均12.2年)。结果 743例颅咽管瘤治疗情况。CT/MR影像复查肿瘤体积变化:肿瘤消失416例(56.0%),明显缩小(>50%)221例(29.7%),无变化65例(8.7%),肿瘤复发41例(5.5%);临床症状:神经功能改善620例(83.4%),无变化73例(9.8%),恶化42例(5.7%),死亡9例(1.2%)。结论临床所见颅咽管瘤多数呈囊实性或囊性,可经此疗法治愈。立体定向内放疗不仅创伤较小,对囊性颅咽管瘤长期疗效也令人满意。 Objective To investigate the long-term results of radiotherapy in craniopharyngioma. Methods A retrospective analysis of 743 patients with cystic craniopharyngioma treated with stereotactic 32 P radiotherapy was performed. The postoperative clinic review and telephone follow-up were 10 to 20 years (average 12.2 years). Results of 743 cases of craniopharyngioma treatment. Tumor volume changes after CT / MR imaging were reviewed: 416 (56.0%) disappeared, 221 (29.7%) significantly reduced (> 50%), 65 (8.7%) had no change and 41 (5.5%) had tumor recurrence; Clinical symptoms: There were 620 cases (83.4%) with improvement of neurological function, 73 cases (9.8%) without change, 42 cases (5.7%) worsening and 9 deaths (1.2%). Conclusions The majority of craniopharyngiomas found in clinic are cystic or cystic and can be cured by this therapy. Stereotactic radiotherapy is not only less traumatic, long-term efficacy of cystic craniopharyngioma is satisfactory.