论文部分内容阅读
利用促血管生成因子促进血管生成已成为当前治疗缺血性疾病研究的一个热点。CD151蛋白作为四跨膜超家族蛋白(transmembrane-4 superfamily proteins,TM4SF)的重要成员之一,其在促血管生成方面起着重要的作用。CD151在体外能促进血管内皮细胞的增值、迁移及管状结构的形成,在体内能增加大鼠缺血后肢和缺血心肌区域的微血管数量,促进血管生成。CD151蛋白作为一个新的促血管生成因子日益受到大家的关注。本文就CD151促血管生成的研究进展进行综述。
The use of pro-angiogenic factors to promote angiogenesis has become a hot spot in the current study of the treatment of ischemic diseases. The CD151 protein is an important member of the transmembrane-4 superfamily proteins (TM4SF) and plays an important role in pro-angiogenesis. CD151 can promote the proliferation, migration and formation of tubular structure in vitro, and increase the number of microvessels in ischemic hindlimb and ischemic myocardium in vivo and promote angiogenesis. As a new angiogenic factor, CD151 protein is receiving more and more attentions every day. This article reviews the progress of CD151 proangiogenesis research.