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Ｎｏｎｏｂｅｓｅｄｉａｂｅｔｉｃ（ＮＯＤ）小鼠是一种遗传性Ⅰ型糖尿病的啮齿动物模型，它从５周龄起自发地出现自身免疫性胰岛炎，１４周龄后可自发Ⅰ型糖尿病［１］。ＮＯＤ鼠糖尿病与人类Ⅰ型糖尿病有许多相似之处［１］。由于ＮＯＤ鼠糖尿病系一器官特异性自身免疫性
Non -obesediabetic (NOD) mice are a type of rodent model of hereditary type I diabetes that spontaneously develop autoimmune insulitis from 5 weeks of age and spontaneously develop type 1 diabetes after 14 weeks of age [1]. NOD mice have many similarities with human type 1 diabetes mellitus [1]. Because NOD mice have an organ-specific autoimmune diabetes