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目的探讨颅脑损伤手术患者脑脊液超敏C反应蛋白(hs-CRP)与脑损伤类型、病情进展及预后的关系。方法颅脑损伤手术患者60例,按颅脑损伤分型及手术方式分为3组,Ⅰ组:单侧硬膜外血肿开颅手术组23例;Ⅱ组:单侧硬膜下血肿开颅手术组22例;Ⅲ组:广泛性脑挫裂伤开颅组15例。采集颅脑损伤患者术中至术后3周的脑脊液,以散射免疫比浊法测定脑脊液hs-CRP的含量,分析其预测各组预后的效果,并与相应影像学资料进行比较。结果术后10d3组脑脊液hs-CRP含量比较差异有统计学意义(P<0.01);hs-CRP含量与脑损伤类型密切相关并可预测颅脑损伤手术患者的预后,hs-CRP的变化与影像学改变亦密切相关。结论脑脊液hs-CRP的含量与不同脑损伤类型、预后密切相关,对判断病情变化有重要意义。
Objective To investigate the relationship between cerebrospinal fluid high-sensitivity C-reactive protein (hs-CRP) and brain injury, progression and prognosis in patients with craniocerebral injury. Methods Sixty patients with craniocerebral injury were divided into three groups according to the type of craniocerebral injury and operation. Group Ⅰ: 23 patients underwent craniotomy for unilateral epidural hematoma; Group Ⅱ: The operation group was 22 cases; the group Ⅲ: 15 cases of extensive brain contusion and craniotomy group. Cerebrospinal fluid of patients with craniocerebral injury was collected intraoperatively and 3 weeks after operation, and the content of hs-CRP in cerebrospinal fluid was determined by scattering immunoprecipitation. The prognosis of each group was analyzed and compared with the corresponding imaging data. Results The content of hs-CRP in cerebrospinal fluid of 10 days after operation was significantly different (P <0.01). The content of hs-CRP was closely related to the type of brain injury and could predict the prognosis, the change of hs-CRP and the imaging of the patients with craniocerebral injury Changes in learning are also closely related. Conclusion The content of hs-CRP in cerebrospinal fluid is closely related to different types of brain injury and prognosis, which is of great significance in judging the change of disease.