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采用致死性５０Ｃｏ一Ｙ射线辐照的小鼠骨髓型放射损伤模型，测定其外周血白细胞、骨髓单个核细胞，应用流式细胞仪分析骨髓造血干／祖细胞，探讨肿瘤坏死因子ａ（ＴＮＦ。）对骨髓造血功能的辐射防护效应．结果表明：辐射前２４ｈ给予ＴＮＦ。处理组在辐照后第１２天，外周血ＷＢＣ、骨髓单个核细胞数量以及骨髓细胞中Ｃ一ｋｉｔ＋细胞百分率都显著高于未经ＴＮＦ。处理组（Ｐ＜０．０１）。提示ＴＮＦ可以保护机体骨髓造血细胞耐受辐射损伤。导师
The mouse bone marrow-type radiation injury model irradiated by 50Co-Y-rays was used to determine the peripheral blood leukocytes and bone marrow mononuclear cells. The bone marrow hematopoietic stem/progenitor cells were analyzed by flow cytometry to investigate the tumor necrosis factor a (TNF). ) Radiation protection effects on bone marrow hematopoietic function. The results showed that TNF was given 24 hours before radiation. On the 12th day after irradiation, the WBC in the peripheral blood, the number of bone marrow mononuclear cells and the percentage of C-kit+ cells in the bone marrow cells in the treatment group were significantly higher than those without TNF. Treatment group (P<0.01). It is suggested that TNF can protect the bone marrow hematopoietic cells from radiation damage. tutor