非运动症状(NMS)是帕金森病(PD)的重要组成部分,相比运动症状,NMS对患者生活质量、陪护花费、疾病负担的影响更大,是“运动前期”的临床生物标记。然而实际临床诊疗中往往更关注运动症状。鉴于大部分令患者无比苦恼的NMS是可治的,重要性被远远低估的NMS成为目前临床重要且刻不容缓的任务和挑战。本文综述NMS的神经病理基础、临床表现以及如何评估和处理。 Non-motor symptoms (NMS) are an important part of Parkinson’s disease (PD). Compared with exercise symptoms, NMS has a greater impact on patients’ quality of life, escort costs and disease burden, and is a “pre-exercise” clinical biomarker . However, the actual clinical diagnosis and treatment tend to be more concerned about motor symptoms. Given that most NMSs that make patients uncomfortable are manageable, the NMS, whose importance is far undervalued, has become an clinically important and urgent task and challenge. This article reviews the neuropathological basis, clinical presentation, and how to evaluate and manage NMS.